Pluripotent stem cells (PSCs) lie at the top of the stem cell hierarchy with the unique features, immortality and pluripotency. PSCs maintain their identity through indefinite proliferation while having an ability to produce all cell types in our body. Due to these interesting features, PSCs have provided an unprecedented experimental system for cellular and developmental biology and translational medicine. However, fundamental mechanisms governing immortality and pluripotency of PSCs have not been fully understood. Our lab is interested in discovering novel molecular and cellular mechanisms for PSC proliferation and differentiation. Furthermore, fundamental principles we discovered in stem cells will be exploited to develop therapeutics for anti-aging.